Disseminated cysticercosis in a non-endemic area of Europe: diagnostic challenges and successful management of an unusual parasitic infection
DOI:
https://doi.org/10.17420/ap71.540Keywords:
disseminated cysticercosis, neurocysticercosis, Taenia solium, pork tapeworm, brain lesions, magnetic resonance, albendazole therapyAbstract
Cysticercosis caused by the larval forms of Taenia solium is observed sporadically in humans from nonendemic areas and is challenging to diagnose. We report an extraordinary case of 81-year-old woman from a rural region of Poland with worsening neurological symptoms suspected of brain malignancy. Imaging and serological tests confirmed disseminated cysticercosis with multiple space-occupying lesions located in the brain, soft tissues, and liver. Systemic cysticercosis in a white woman without a history of international travel is an exceptional clinical finding. Treatment with albendazole and corticosteroids led to significant reduction of pathological masses and clinical improvement. This case highlights the importance of considering unusual parasitic infections in neurological evaluations, even in non-endemic areas.
References
[1] Garcia H.H., Gonzalez A.E., Gilman R.H. 2020. Taenia solium cysticercosis and its impact in neurological disease. Clinical Microbiology Reviews 33(3): e00085-19. https://doi.org/10.1128/CMR.00085-19
[2] Garcia H.H., Rodriguez S., Friedland J.S. 2014. Immunology of Taenia solium taeniasis and human cysticercosis. Parasite Immunology 36(8): 388–396. https://doi.org/10.1111/pim.12126
[3] White A.C., Coyle C.M. Jr., Rajshekhar V., Singh G., Hauser W.A., Mohanty A., Garcia H.H., Nash T.E. 2018. Diagnosis and treatment of neurocysticercosis: 2017 clinical practice guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH). Clinical Infectious Diseases 66(8): e49–e75. https://doi.org/10.1093/cid/cix1084
[4] Filho P.T.H., Norcia L.F., Fleury A., Zanini M.A. 2024. Current role of surgery in the treatment of neurocysticercosis. Pathogens 13(3). https://doi.org/10.3390/pathogens 13030218
[5] Garcia H.H., Nash T.E., Del Brutto O.H. 2014. Clinical symptoms, diagnosis, and treatment of neurocysticercosis. The Lancet Neurology 13(12): 1202–1215. https://doi.org/10.1016/S1474-4422(14)70094-8
[6] Latif A., Kapoor V., Weum B., Mirza M., Velagapudi M. 2019. A curious case of disseminated cysticercosis in an immunocompetent adult. Intractable & Rare Diseases Research 8(4): 283–285. https://doi.org/10.5582/irdr.2019.01093
[7] Dev N., Abbas S.Z. 2019. Disseminated cysticercosis. The New England Journal of Medicine 380(13): 1267. https://doi.org/10.1056/NEJMicm1810953
[8] Sardana V., Ojha P., Sharma D., Sharma S.K., Saxena S., Rai N.N. 2016. Disseminated cysticercosis. Neurology India 64(5): 1058–1060. https://doi.org/10.4103/0028-3886.190237
[9] Singh S., Jaiswal V., Tiwari S., Yadav S. 2023. Revisiting extracranial cysticercosis: a rare case series of mycoparasitism affecting the cervicofacial region from an endemic zone. National Journal of Maxillofacial Surgery 14(2): 317–320. https://doi.org/10.4103/njms.njms_141_22
[10] Ilyas M., Mahajan V. 2023. Disseminated wholebody cysticercosis. Radiology 309(1): e231317. https://doi.org/10.1148/radiol.231317
[11] Franco R.G., Gomez A.A., Cerda J.G., Roa M.G., Neria P.R. 2020. Submacular cysticercosis successfully treated through conservative management: case report. Case Reports in Ophthalmology 11: 315–321. https://doi.org/10.1159/000508030
[12] Fung K.F.K, Dixe de Oliveira Santo I., Pooyan A., Gala F., Aswani Y. 2025. Disseminated cysticercosis. Radiographics 45(2): e240244. https://doi.org/10.1148/rg.240244
[13] George J., Goel V., Agarwal A., Vishnu V.Y., Garg A., Srivastava M.P. 2022. Disseminated cysticercosis – should we treat? Tropical Doctor 52(3): 444–445. https://doi.org/10.1177/00494755221084387
[14] Singh R.P. 2014. Intramuscular cysticercosis – the solitary reaper. Annals of African Medicine 13(1): 53–54. https://doi.org/10.4103/1596-3519.126955
[15] Ratnika Adil M., Amin S.S., Kulhari M. 2022. Disseminated cysticercosis masquerading as mucocutaneous nodules. Indian Dermatology Online Journal 13(5): 629–632. https://doi.org/10.4103/idoj.idoj_40_22
[16] Elwell Z., Bearelly S., Aboul-Nasr K., Lara J. 2021. Unilateral cysticercosis of the parotid gland: case report, diagnosis, and clinical management. Case Reports in Otolaryngology 2021: 9999441. https://doi.org/10.1155/2021/9999441
[17] Goyal S., Goyal S. 2022. Cysticercosis; a case of missed diagnosis. Diagnostic Cytopathology 50(80): E214–E216. https://doi.org/10.1002/dc.24957
[18] Goenka A.H. 2023. Disseminated cysticercosis. American Journal of Tropical Medicine and Hygiene 89(5): 1033. https://doi.org/10.4269/ajtmh.13-0242a
[19] Rodrigues A., Neves D., Maury I., Sargento D., Pereira A. 2018. A classic neurocysticercosis case with an unusual complication. European Journal of Case Reports in Internal Medicine 5(1): 000762. https://doi.org/10.12890/2017_000762
[20] Póvoa A., Vieira P., Silva A., Pantazi I., Correia J. 2021. Disseminated cysticercosis. European Journal of Case Reports in Internal Medicine 8(3): 002430. https://doi.org/10.12890/2021_002430
[21] Garcia H.H., Lescano A.G., Gonzales I., Bustos J.A., Pretell E.J., Horton J., Saavedra H., Gonzalez A.E., Gilman R.H. 2016. Cysticidal efficacy of combined treatment with praziquantel and albendazole for parenchymal brain cysticercosis. Clinical Infectious Diseases 62(11): 1375–1379. https://doi.org/10.1093/cid/ciw134
[22] Laranjo-González M., Devleesschauwer B., Trevisan C., Allepuz A., Sotiraki S., Abraham A., Afonso M.B., Blocher J., Cardoso L., Correia da Costa J.M., Dorny P., Gabriël S., Gomes J., Gómez- Morales M.Á., Jokelainen P., Kaminski M., Krt B., Magnussen P., Robertson L. J., Dermauw V. 2017. Epidemiology of taeniosis/ cysticercosis in Europe, a systematic review: Western Europe. Parasites & Vectors 10: 349. https://doi.org/10.1186/s13071-017-2280-8
[23] Rodriguez S., Wilkins P., Dorny P. 2012. Immunological and molecular diagnosis of cysticercosis. Pathogens and Global Health 106(5): 286–298. https://doi.org/10.1179/ 2047773212Y.0000000048