Ultrasonic cavitation and decasan irrigation for residual cavity management in liver cystic echinococcosis: a retrospective comparative study from an endemic region

Authors

  • Duschan Shukhratovich Sapaev Department of General Surgery, Urgench State Medical Institute, 28 Al-Khorezmy Street, Urgench 220100, Uzbekistan
  • Farkhod Radjabovich Yakubov Department of General Surgery, Urgench State Medical Institute, 28 Al-Khorezmy Street, Urgench 220100, Uzbekistan
  • Daniyar Shamuratovich Xodjiev Department of General Surgery, Urgench State Medical Institute, 28 Al-Khorezmy Street, Urgench 220100, Uzbekistan
  • Kudratbek Bakhtiyarovich Babajanov Department of General Surgery, Urgench State Medical Institute, 28 Al-Khorezmy Street, Urgench 220100, Uzbekistan
  • Nizamaddin Daniyar ogli Sultan Zada Department of General Surgery, Urgench State Medical Institute, 28 Al-Khorezmy Street, Urgench 220100, Uzbekistan
  • Navruz Odilbek ogli Matkurbonov Department of General Surgery, Urgench State Medical Institute, 28 Al-Khorezmy Street, Urgench 220100, Uzbekistan
  • Jasurbek Islombekovich Shonazarov Department of General Surgery, Urgench State Medical Institute, 28 Al-Khorezmy Street, Urgench 220100, Uzbekistan
  • Komila Khujayazovna Khayitboeva Department of Endocrinology, Urgench State Medical Institute, 28 Al-Khorezmy Street, Urgench 220100, Uzbekistan

DOI:

https://doi.org/10.17420/ap71.552

Keywords:

liver echinococcosis, purulent-septic complications, ultrasonic cavitation, residual cavity, postoperative drainage, Decasan solution

Abstract

Most often, Echinococcus parasitizes in the liver, causing the need for surgical treatment, the results of which currently do not meet expert expectations due to the high frequency of postoperative complications and the risk of relapse. The aim of the study is to improve the results of surgical treatment of liver echinococcosis by improving the tactical aspects of treatment and elimination of the residual cavity after echinococcectomy to prevent the development of purulent-septic complications. The object of the study was 442 patients with liver echinococcosis treated in the abdominal surgery of the Khorezm Regional Multidisciplinary Medical Center for the period from 2010 to 2023. To achieve the research goal and address the objectives, the following methods were used: general clinical, biochemical, instrumental and statistical methods. When determining the tactics and volume of surgical intervention, we recommend using the proposed method for treating the residual cavity using ultrasonic cavitation and a 0.02% Decasan solution, which minimized the development of purulent-septic complications in the immediate and long-term period after surgery. The new approach significantly reduced postoperative drainage needs (63.8% vs 36.6%, P < 0.001), complications (12.5% vs 5.4%, P < 0.001), and increased uncomplicated recovery (93.1% vs 80.0%). Drainage duration decreased from 11.3% to 3.5% in the long-term follow-up.

References

[1] World Health Organization. 2020. Ending the neglectto attain the sustainable development goals: aroadmap for neglected tropical diseases 2021–2030. Geneva. Available from: https://www.who.int/publications/i/item/9789240010352.

[2] Akkucuk S., Aydogan A., Ugur M., Yetim T., DavranR., Oruc C., Kilic E., Temiz M. 2014. Comparison of surgical procedures and percutaneous drainage in thetreatment of liver hydatid cysts. International Journal of Clinical and Experimental Medicine 7(8): 2280–2285.

[3] Sapaev D.S., Ruzibaev R.Y., Yakubov F.R. 2018. [Modern comprehensive diagnostics and surgicaltreatment of complicated forms of liverechinococcosis]. Grekov’s Bulletin of Surgery177(4): 19–22 (in Russian). https://doi.org/10.24884/0042-4625-2018-177-4-19-22

[4] Wen H., Vuitton L., Tuxun T., Li J., Vuitton D.A., Zhang W., McManus D.P. 2019. Echinococcosis: advances in the 21st century. Clinical MicrobiologyReviews 32(2): e00075-18. https://doi.org/10.1128/CMR.00075-18

[5] Federal Service for Surveillance on Consumer RightsProtection and Human Wellbeing. 2017. State reporton the sanitary and epidemiological welfare in theRussian Federation. Moscow: Rospotrebnadzor (inRussian).

[6] Babadjanov A.K., Yakubov F.R., Ruzmatov P.Y., Sapaev D.S. 2021. Epidemiological aspects of echinococcosis of the liver and other organs in theRepublic of Uzbekistan. Parasite Epidemiology and Control 15: e00230. https://doi.org/10.1016/j.parepi.2021.e00230

[7] Tuxun T., Zhang J.H., Zhao J.M., Shi C.Z., ChenX.C., Wen H. 2014. World review of laparoscopictreatment of liver cystic echinococcosis: 914 patients.International Journal of Infectious Diseases 24: 43–50. https://doi.org/10.1016/j.ijid.2014.01.012

[8] Akhmedov S.M., Ibrokhimov N.K., Safarov B.D., Rasulov N.A. 2014. [Liver resection forechinococcosis]. Annaly Khirurgicheskoy Gepatologii 19(2): 49–55 (in Russian).

[9] Richter J. 2015. Anaphylactic shock ensuingtherapeutic puncture of an echinococcal cyst.Parasitology Research 114(2): 763–766. https://doi.org/10.1007/s00436-014-4313-y

[10] Botezatu C., Mastalier B., Patrascu T. 2018. Hepatichydatid cyst – diagnosis and treatment algorithm. Journal of Medicine and Life 11(3): 203–209. https://doi.org/10.25122/jml-2018-0045

[11] Özdemir Y., Ozer İ., Sürmelioğlu A., Dalgı. T., Aksoy E., .aparlar M.A., Ulaş M, Özoğul Y.B., Bostancı E.B., Akoğlu M. 2022. Risk factorsdetermining bile leakage after multiple liver hydatidcyst surgery. Journal of Surgery and Medicine 6(3): 306–312. https://doi.org/10.28982/josam.1072054

[12] Reyimu A., Tiemin J., Yingmei S., Xuepeng Z., Wenjiang G., Yuhao D., Halimulati D, Ababokeli W, Tuerganaili A, Hao W. 2024. Treatment of cavernoustransformation of portal vein caused by hepatic cysticechinococcosis using ex vivo liver resection andautotransplantation. Annals of Transplantation 29: e942358. https://doi.org/10.12659/aot.942358

[13] Ortiz De Elguea-Lizarraga J.I., Koi A., StevensonH.L., Bilek J.M., Gosnell J., Wilhelm A.B., McLellan S., Kueht M.L. 2023. Liver resection for cysticechinococcosis: emergence of a non-endemic disease. American Surgeon 89(12): 6356–6358. https://doi.org/10.1177/00031348231175491

[14] Azizoğlu M., Aydogdu B., Kamci T.O., Arslan S., Basuguy E., Bilici S., Okur M.H. 2024. Analysis of complications of a neglected disease: 13 years of experience with liver hydatid cysts in a high-volumehospital. Medicina (Kaunas) 60(10): 1696. https://doi.org/10.3390/medicina60101696

[15] Farhat W., Ammar H., Rguez A., Harrabi F., SaidM.A., Ghabry L., Gupta R., Ben Cheikh A., Ghali H., Ben Rajeb M., Ben Mabrouk M., Ben Ali A. 2022. Radical versus conservative surgical treatment of liver hydatid cysts: a paired comparison analysis.American Journal of Surgery 224(1): 190–195. https://doi.org/10.1016/j.amjsurg.2021.12.014

[16] Jaén-Torrejimeno I., Ramia J.M., López-Guerra D., Rojas-Holguín A., De-Armas-Conde N., Blanco-Fernández G. 2023. Textbook outcome in the surgicaltreatment of liver hydatid cyst. Surgery 173(2): 429–434. https://doi.org/10.1016/j.surg.2022.09.020

[17] Abbasi Dezfouli S., El Rafidi A., Aminizadeh E., Ramouz A., Al-Saeedi M., Khajeh E., Mieth M., Weber T.F., Chang D.H., Hoffmann K., BüchlerM.W., Mehrabi A. 2023. Risk factors andmanagement of biliary leakage after endocystectomy for hepatic cystic echinococcosis. PLoS NeglectedTropical Diseases 17(6): e0011724. https://doi.org/10.1371/journal.pntd.0011724

[18] Wang Z., Zhu H.H., Yang J.Y., Wang Y., Gai Z.G., Ma F.C., Yang D.W. 2021. Laparoscopic versusconventional open treatment of hepatic cystichydatidosis: a systematic review and meta-analysis of cohort studies. Videosurgery and Other MiniinvasiveTechniques 17(3): 406–417. https://doi.org/10.5114/wiitm.2022.115225

[19] Yakubov F.R., Sapaev D.S. 2022. Surgical treatment of liver echinococcosis. Journal of Medicine and Life15(11): 1409–1414. https://doi.org/10.25122/jml-2022-0268

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Published

2025-11-16

How to Cite

Sapaev, D. S., Yakubov, F. R., Xodjiev, D. S., Babajanov, K. B., Sultan Zada, N. D. ogli, Matkurbonov, N. O. ogli, … Khayitboeva, K. K. (2025). Ultrasonic cavitation and decasan irrigation for residual cavity management in liver cystic echinococcosis: a retrospective comparative study from an endemic region. Annals of Parasitology, 71, 00–00. https://doi.org/10.17420/ap71.552

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